Name: ARA-290 10mg (Research Peptide)
Brand: Verum Peptides
Price: 59 USD
Availability: InStock

Identification

Chemical name	Linear 11-residue polypeptide with an N-terminal pyroglutamate, corresponding to the aqueous-exposed face of helix B of human erythropoietin
Common designation	ARA-290; cibinetide; helix B surface peptide (HBSP)
Sequence	pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
N-terminus	Pyroglutamate, cyclised by loss of ammonia from glutamine
Molecular formula	C51H84N16O21
Molecular weight	1257.3 g/mol
CAS number	1208243-50-8
Molecular target	Heteromeric complex of the erythropoietin receptor and the beta-common receptor, CD131. Referred to in the primary literature as the innate repair receptor.
Not a target	The classical homodimeric erythropoietin receptor. The sequence excludes the region that binds it.
Physical form	White lyophilized powder
Quantity supplied	10 mg nominal per unit
Country of manufacture	United States

Note on receptor selectivity

Erythropoietin engages two structurally distinct receptor populations: the classical homodimer, and a heteromeric complex of the erythropoietin receptor with the beta-common receptor. ARA-290 corresponds only to the helix-B surface region, which is not the region that binds the homodimer.

That makes this peptide useful as a selectivity reagent for experiments distinguishing signalling through one complex from the other. It does not reproduce the activity of erythropoietin and is not a substitute for it in any assay.

Certificate of analysis - current lot

The interactive verification record for this product is shown below, followed by the same information reproduced as text on this page and the full certificate as a document. The record does not depend on the embed loading.

Certificate of analysis - lot ARA1008212025-02

Lot record

ARA1008212025-02

Testing laboratory	Freedom Diagnostics, United States
Laboratory relationship	Independent third party. Not owned by, affiliated with, or operated by Verum.
Sample received	8 December 2025
Results reported	10 December 2025
Accession reference	2512080020
Analytical method	High-performance liquid chromatography with ultraviolet detection coupled to mass spectrometry (HPLC-UV / LC-MS)

Results, this lot

Identity, LC-MS	Confirmed as ARA-290
Purity, HPLC-UV	99.893 %
Net peptide content	12.75 mg per unit
Appearance	White lyophilized powder
Mass confirmation	Ions observed at m/z 629.23 [M+2H]2+ and 1257.18 [M+H]+, both consistent with the expected molecular weight

Purity and content figures above are specific to lot ARA1008212025-02 and are not a specification carried across other lots. Each lot is tested individually and reports its own results. The certificate supplied with your unit records the results for that lot.

Testing scope

Panels differ between products and between lots. What follows is the scope of testing performed on this lot. Nothing is claimed unless it appears on the certificate for the lot supplied.

Performed

✓	Identity by LC-MS
✓	Purity by HPLC-UV
✓	Net peptide content
✓	Appearance by visual inspection
✓	Mass confirmation, two charge states

Not performed

-	Bacterial endotoxin
-	Sterility
-	Microbial enumeration
-	Elemental impurities
-	Residual solvents
-	Cyclisation completeness at the N-terminus

On this sequence the last entry is worth noting specifically. Incomplete cyclisation of the N-terminal residue leaves an open-chain species 17 daltons heavier with different stability behaviour. It is resolvable on a mass trace but is not quantified as a separate parameter on this certificate. Where a parameter is material to intended laboratory work, purchasers should verify it independently or source material released against that specification.

Storage and laboratory handling

Lyophilized powder, transit	Stable at ambient temperature during shipping and short-term handling. Cold-chain transport is not required.
Lyophilized powder, storage	−20 °C, protected from light, container tightly closed
Solubility	Sterile laboratory-grade water or a defined aqueous buffer appropriate to the assay
Solution, storage	2 °C to 8 °C, protected from light. Materially less stable than the dry powder.
Freeze-thaw	Avoid repeated cycles. Aliquot at first preparation where the protocol allows.
Sequence-specific note	The pyroglutamate N-terminus resists aminopeptidase attack. The asparagine and serine positions toward the C-terminus carry deamidation liability in aqueous storage, so alkaline conditions should be avoided and preparations made close to the time of use.
Personal protection	Handle under standard laboratory conditions with gloves, eye protection and a laboratory coat.

Preparation conditions are the responsibility of the receiving laboratory. Verum provides no protocol, no preparation instruction, and no guidance on use.

Published literature

References are listed for bibliographic purposes and are indexed by the experimental system used. Each description states what the study measured, not what it concluded. Studies conducted in human participants are excluded. Verum has no involvement in any of this work and makes no representation as to its applicability.

Cell culture
& rodent

2008

Derivation of non-erythropoietic peptides from the tertiary structure of erythropoietin

Brines M, Patel NS, Villa P, et al. · Proceedings of the National Academy of Sciences 105(31):10925

Derived candidate peptides from the tertiary structure of erythropoietin, assayed them in cell culture and rodent models, and separately measured erythropoietic activity to establish whether the two activities had been decoupled. The founding characterisation of this compound and of the helix-B design approach.

PubMed 18676614 →

Genetic
rodent model

2018

Engagement of the EPOR–beta common receptor complex in a genetic rodent model

Bitto A, Irrera N, Pizzino G, et al. · Biochimica et Biophysica Acta, Molecular Basis of Disease 1864(2):632–639

Measured tissue-level markers and closure kinetics in a genetically modified rodent strain, with receptor-complex engagement as the mechanism under test. A worked example of how the receptor hypothesis has been probed in an intact animal rather than in culture.

PubMed 29223734 →

Endothelial
progenitors

2016

Endothelial progenitor cell responses to a selective EPOR–CD131 heteroreceptor agonist

Hache G, Garrigue P, Bennis Y, et al. · Shock 46(4):390–397

Measured angiogenic capacity and homing behaviour of circulating endothelial progenitor cells. A different cell population and different readouts from the other entries, useful for testing whether the receptor hypothesis generalises across tissue types.

PubMed 27172159 →

Work conducted in cultured cells and rodents does not establish an effect in any other system. Nothing in the above is offered as a representation about this material.

Regulatory status

United States	Not approved by the FDA for any indication. Not on the section 503A bulk drug substances list.
Orphan designation	An orphan drug designation was granted for a rare disease indication and was never converted into a marketing approval in any jurisdiction. Orphan designation is a development incentive granted early in a programme, not a determination about safety or efficacy. The two are frequently conflated in writing about this compound.
Other jurisdictions	No marketing authorisation is held anywhere. There is no approved product and no ongoing pharmacovigilance behind this molecule.
Status date	Accurate as of August 2026. Verify the current position independently.

Purchase eligibility

By placing an order you confirm each of the following:

✓	You are at least 21 years of age.
✓	You are a qualified researcher, or are purchasing on behalf of a research institution or commercial laboratory.
✓	The material will be used solely for in vitro laboratory research.
✓	The material will not be administered to humans or to animals, and will not be resold or transferred for any such purpose.
✓	You are responsible for compliance with all federal, state and local law governing receipt, handling, storage and use.

Confirmation is recorded at checkout against your order. Verum reserves the right to decline or cancel any order.

Supply

Orders placed before the daily cutoff are dispatched the same day from our United States warehouse. Domestic orders typically arrive within two business days. A tracking reference is issued by email once the consignment leaves the facility. Each unit carries a scannable code linking to the certificate for its own lot.

Not for human or veterinary use. Not for use in diagnostic or therapeutic procedures. This product is a laboratory reagent. Nothing on this page constitutes medical advice, a recommendation for personal use, or a representation that this material is safe or effective for any purpose. No statement here has been evaluated by the U.S. Food and Drug Administration.