MOTS-C

Note on the genomic origin

Essentially every signalling peptide a researcher works with is encoded in nuclear DNA. This one is not. Its open reading frame sits nested inside the 12S ribosomal RNA gene of the mitochondrial genome, a genome carrying only a handful of genes and long assumed to encode nothing but components of the respiratory machinery. It belongs to a small class of mitochondrial-derived peptides identified since the mid-2000s.

That origin has a practical consequence for experimental design. Published work reports movement between subcellular compartments under metabolic stress, so a peptide of this class is not fully characterised by what happens at a cell surface receptor, and assays built only around extracellular exposure may be measuring a fraction of the picture. Subcellular localisation is a variable here in a way it is not for most of this catalogue. The reference below sets out the evidence for that directly.

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The interactive verification record is shown below, followed by the same information reproduced as text on this page and the full certificate as a document. The record does not depend on the embed loading.

Certificate of analysis - lot MOT10-052026-4

Lot record

MOT10-052026-4

Results, this lot

The mass confirmation on this peptide is unusually informative. Four independent charge states that all reconstruct to the same molecular weight is a stronger identity argument than a single ion, because a truncated or oxidised species shifts the entire ladder rather than hiding within one peak. Take any one of the figures above, multiply by its charge, subtract the protons, and check that you arrive near 2175. Purity, content and endotoxin figures are specific to lot MOT10-052026-4 and are not specifications carried across other lots.

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Panels differ between products and between lots. What follows is the scope of testing performed on this lot. Nothing is claimed unless it appears on the certificate for the lot supplied.

The first two entries in the right-hand column matter more on this sequence than on most. Five of sixteen residues carry oxidation liability and each fails differently, so a sample can accumulate several modifications at once. A purity figure measured at one wavelength will not separate the resulting mixture cleanly. Where a parameter is material to intended laboratory work, purchasers should verify it independently.

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Sixteen residues, five of them vulnerable to oxidation: two methionines, a tryptophan and two tyrosines. Nothing else in this catalogue carries that concentration of liability in so short a chain, and it is the single most important handling fact about this material.

Each fails differently. Methionine oxidises to the sulfoxide, sixteen daltons heavier and frequently co-eluting with the parent. Tryptophan is vulnerable to light as well as to oxidants. Tyrosine can oxidise and cross-link.

One instruction follows for anyone buying across this catalogue: keep this peptide away from copper. GHK-Cu and the blends built around it are redox-active copper complexes, and copper plus a methionine-rich sequence is the chemistry described above, accelerated. Do not share buffers, do not combine working solutions, and treat labware that has carried a copper complex as unsuitable for this material.

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Preparation conditions are the responsibility of the receiving laboratory. Verum provides no protocol, no preparation instruction, and no guidance on use.

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Both entries below are linked so they can be read at source. Descriptions state what each study measured, not what it concluded. No intervention study administering this peptide to human participants has been published. Verum has no involvement in either piece of work and makes no representation as to its applicability.

Work conducted in cultured cells and mice does not establish an effect in any other system. Nothing above is offered as a representation about this material.

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By placing an order you confirm each of the following:

Confirmation is recorded at checkout against your order. Verum reserves the right to decline or cancel any order.

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Orders placed before the daily cutoff are dispatched the same day from our United States warehouse. Domestic orders typically arrive within two business days. A tracking reference is issued by email once the consignment leaves the facility. Each unit carries a scannable code linking to the certificate for its own lot.

Not for human or veterinary use. Not for use in diagnostic or therapeutic procedures. This product is a laboratory reagent. Nothing on this page constitutes medical advice, a recommendation for personal use, or a representation that this material is safe or effective for any purpose. No statement here has been evaluated by the U.S. Food and Drug Administration.